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Related Experiment Videos

Trace element concentrations in commonly used intravenous fluids.

J G Brock-Utne, S J O'Keefe, R Cremer

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |March 19, 1983
    PubMed
    Summary

    Essential trace elements in South African intravenous fluids are minimal, except in fresh freeze-dried plasma (FDP). FDP alone does not meet daily requirements for patients on total parenteral nutrition, necessitating additional trace element supplements.

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    Area of Science:

    • Clinical Chemistry
    • Nutritional Science
    • Pharmacology

    Background:

    • Intravenous fluids are critical for patient care, especially for those requiring nutritional support.
    • Essential trace elements play vital roles in numerous physiological processes.
    • Understanding the trace element content of commonly used intravenous fluids is crucial for optimizing patient nutrition.

    Purpose of the Study:

    • To quantify the concentrations of essential trace elements in various intravenous fluids utilized in South Africa.
    • To assess the adequacy of these fluids in meeting the daily trace element requirements for patients, particularly those on total parenteral nutrition.

    Main Methods:

    • Analysis of essential trace element concentrations in a range of intravenous fluid preparations.

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  • Comparison of measured trace element levels against established recommended daily intake guidelines.

    • Main Results:

    • Most intravenous fluids contained negligible amounts of essential trace elements.
    • 4% human serum albumin and fresh freeze-dried plasma (FDP) showed higher concentrations.
    • FDP, despite containing significant zinc, copper, iron, and chromium, was insufficient to meet recommended daily requirements when administered at typical doses (1-2 units/week) for total parenteral nutrition.

    Conclusions:

    • Standard intravenous fluids are inadequate sources of essential trace elements.
    • Fresh freeze-dried plasma (FDP) offers some essential trace elements but is insufficient alone for patients requiring total parenteral nutrition.
    • Supplemental intravenous trace element administration is necessary for patients on total parenteral nutrition to prevent deficiencies.