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Haematological reference values for the Basotho.

J P Cross, A D Heyns

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |March 26, 1983
    PubMed
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    Establishing haematological reference values for Basotho adults revealed apparent neutropenia and sex differences in lymphocytes. Inadequate health criteria affected results, with many females showing low ferritin, impacting haemoglobin reference values.

    Area of Science:

    • Hematology
    • Population Health
    • Clinical Biochemistry

    Background:

    • Establishing accurate haematological reference values is crucial for diagnosing and managing health conditions.
    • Previous studies have suggested potential differences in haematological parameters among different ethnic groups.
    • Defining strict health criteria is essential for reliable reference value determination.

    Purpose of the Study:

    • To establish haematological reference values for a healthy adult Basotho population.
    • To investigate apparent neutropenia and sex-based differences in lymphocyte counts within this population.
    • To highlight the impact of health criteria on reference value accuracy.

    Main Methods:

    • Statistical analysis of haematological data from a defined population of healthy adult Basotho.

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  • Observation and documentation of specific haematological parameters, including neutrophil and lymphocyte counts.
  • Evaluation of health criteria, including serum ferritin levels, in apparently healthy individuals.
  • Main Results:

    • Apparent neutropenia in Black individuals was observed, consistent with existing literature.
    • An apparent sex difference in lymphocyte counts was noted.
    • A significant proportion (42%) of apparently healthy females exhibited low serum ferritin levels.
    • Low ferritin levels could lead to a 1 g/dl error in haemoglobin reference values.
    • Only 34% of apparently healthy females met all predefined health criteria.

    Conclusions:

    • Haematological reference values for Basotho adults require careful consideration of ethnic and sex-specific factors.
    • Inadequate health screening, particularly regarding iron status (serum ferritin), can significantly skew reference values.
    • Revised health criteria are necessary for accurate haematological reference value determination in diverse populations.