Related Experiment Videos
Characteristics of decrease of plasma gastrin by glucagon in man
The Tohoku Journal of Experimental Medicine
|February 1, 1983
Summary
Glucagon administration lowers plasma gastrin by inhibiting its release from the antrum, not by increasing kidney extraction. This study clarifies the mechanism behind glucagon
Area of Science:
- Gastroenterology
- Endocrinology
- Physiology
Background:
- Exogenous glucagon administration is known to decrease plasma gastrin levels.
- The precise mechanism underlying this observed decrease in plasma gastrin remains incompletely understood.
Purpose of the Study:
- To investigate the mechanism by which glucagon affects plasma gastrin concentrations.
- To determine if glucagon inhibits gastrin release from the antrum or enhances its renal clearance.
Main Methods:
- Measurements of antral gastrin concentrations and plasma gastrin levels before and during glucagon infusion in nine healthy individuals.
- Assessment of renal gastrin extraction by measuring plasma gastrin levels in the renal artery and vein during glucagon infusion in six patients.
Main Results:
- Glucagon administration led to a significant increase in antral gastrin concentration.
- Concurrently, plasma gastrin levels significantly decreased during glucagon infusion.
- A significant reduction in the percent extraction of gastrin by the kidney was observed.
Conclusions:
- Glucagon inhibits the release of gastrin from the gastric antrum.
- The decrease in plasma gastrin levels induced by glucagon is primarily due to reduced antral release, not accelerated renal excretion.