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Hypotensive agent from Cynomorium coccineum.

M Ikram, M S Dar, T Fakouhi

Pahlavi Medical Journal

|April 1, 1978

Summary

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The Iranian plant Cynomorium coccineum shows significant blood pressure lowering effects, primarily in its fresh juice. Water-soluble components of the fresh juice are most potent, suggesting an inorganic active compound.

Area of Science:

Pharmacology
Ethnobotany
Phytochemistry

Background:

Cynomorium coccineum is an Iranian plant with traditional uses.
Investigating its pharmacological properties is crucial for potential therapeutic applications.

Purpose of the Study:

To investigate the blood pressure lowering activity of Cynomorium coccineum.
To identify the active components responsible for the observed depressor effects.

Main Methods:

Chemical isolation and fractionation of plant extracts.
Testing depressor activity in canine models.
Spectroscopic analysis (IR, Mass) and elemental analysis of active fractions.

Main Results:

Fresh juice of Cynomorium coccineum exhibited significant blood pressure lowering activity in dogs.

Related Experiment Videos

Dried plant fractions lacked notable depressor activity.

Water-soluble fractions of the fresh juice showed strong activity.

Active fractions suggested an inorganic nature with low carbon and hydrogen content.

Conclusions:

The blood pressure lowering activity of Cynomorium coccineum is primarily associated with its fresh juice.
The active compounds appear to be inorganic, possibly with a unique molecular structure.
Further research is needed to elucidate the exact nature and mechanism of these inorganic compounds.