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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
08:27

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

[Use of antibiotic-resistant Bifidobacterium in treating ulcerative-necrotic enterocolitis in young children]

B V Pinegin, V M Korzhunov, N P Ivanova

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |January 1, 1983
    PubMed

    Insights

    Antibiotic-resistant bifidobacteria combined with antibiotics significantly improved clinical recovery and restored gut microbiota in premature infants with ulceronecrotic colitis, outperforming commercial bifidobacteria or antibiotics alone.

    Area of Science:

    • Gastroenterology
    • Microbiology
    • Neonatology

    Context:

    • Ulceronecrotic colitis in premature infants often leads to severe intestinal dysbacteriosis.
    • This dysbiosis involves increases in Escherichia, enterococci, staphylococci, and opportunistic enterobacteria like Klebsiella, Serratia, Citrobacter, and Proteus.

    Purpose:

    • To evaluate the efficacy of antibiotic-resistant bifidobacteria in restoring gut microbiota and improving clinical outcomes in premature infants with ulceronecrotic colitis.

    Summary:

    • Infants receiving antibiotic-resistant bifidobacteria with antibiotics showed clinical convalescence in 2 weeks, unlike those treated with antibiotics alone or commercial bifidobacteria.
    • This group also exhibited the most effective recovery of intestinal microflora, with decreased pathogenic bacteria and increased endogenous lactobacilli and bifidobacteria.
    • Antibiotic-resistant bifidobacteria were shown to colonize the infant gut effectively post-treatment.

    Impact:

    • The findings suggest that antibiotic-resistant bifidobacteria are a promising therapeutic agent for managing intestinal dysbiosis in premature infants with ulceronecrotic colitis.
    • This approach offers a potential strategy to improve treatment outcomes and reduce complications associated with gut dysbiosis in this vulnerable population.

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