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Hyperthermia increases aminoglycoside ototoxicity.

K R Henry, M B Guess, R A Chole

    Acta Oto-Laryngologica
    |March 1, 1983
    PubMed
    Summary
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    Elevated body temperature significantly increased kanamycin-induced ototoxicity in young mice, highlighting a potential risk for humans treated with aminoglycoside antibiotics during fever.

    Area of Science:

    • Ototoxicology
    • Auditory Neuroscience
    • Pharmacology

    Background:

    • Aminoglycoside antibiotics and loud noise can cause similar inner ear damage.
    • Body temperature is known to affect cochlear function and noise-induced hearing loss.

    Purpose of the Study:

    • To investigate the effect of elevated body temperature on kanamycin-induced ototoxicity.
    • To determine if hyperthermia exacerbates aminoglycoside ototoxicity.

    Main Methods:

    • Preweanling mice were exposed to environmentally elevated body temperatures (approx. 1°C above normal adult).
    • Kanamycin ototoxicity was assessed by measuring auditory brainstem response (ABR) thresholds.
    • Control groups included mice injected with kanamycin at room temperature and non-injected hyperthermic mice.

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    Main Results:

    • Kanamycin ototoxicity was significantly higher in mice with elevated body temperatures (20.4 dB threshold elevation) compared to controls (9.3 dB).
    • Hyperthermia alone did not affect auditory thresholds in the absence of kanamycin.

    Conclusions:

    • Elevated body temperature enhances kanamycin-induced ototoxicity in developing mice.
    • This finding suggests a potential increased risk of hearing damage in humans with fever receiving aminoglycoside treatment.