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Environmental determinants, liver function, and high density lipoprotein cholesterol levels.

L H Kuller, S B Hulley, R E LaPorte

    American Journal of Epidemiology
    |April 1, 1983
    PubMed
    Summary

    Alcohol consumption impacts high-density lipoprotein cholesterol (HDL-chol) levels, primarily through altered liver function. However, obesity

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    Area of Science:

    • Cardiovascular Disease Research
    • Metabolic Health Studies
    • Liver Function Analysis

    Background:

    • High-density lipoprotein cholesterol (HDL-chol) is a key marker inversely associated with coronary heart disease (CHD) risk.
    • Environmental factors influencing CHD risk may operate through modifications in HDL-chol levels.
    • The precise mechanisms linking environmental exposures to HDL-chol concentrations remain incompletely understood.

    Purpose of the Study:

    • To investigate the role of liver function as a potential mediator between environmental risk factors and HDL-chol levels.
    • To examine how factors like alcohol consumption and obesity affect HDL-chol through changes in liver function.

    Main Methods:

    • Assessed liver function using liver enzyme measurements in distinct study groups.

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  • Included marathon runners, individuals with alcoholism, and participants from the Multiple Risk Factor Intervention Trial (MRFIT).
  • Correlated liver enzyme levels with known CHD risk factors and alcohol consumption patterns.

    • Main Results:

    • Liver function, indicated by enzyme levels, demonstrated a relationship with both CHD risk factors and alcohol intake.
    • Findings suggest that alcohol-induced increases in HDL-chol are largely mediated by changes in liver function.
    • The association between obesity and HDL-chol levels was not explained by the measured alterations in liver function.

    Conclusions:

    • Liver function plays a significant mediating role in the relationship between alcohol consumption and elevated HDL-chol.
    • The mechanisms by which obesity influences HDL-chol are independent of liver function changes.
    • Further research is needed to elucidate the complex interplay between environmental factors, liver function, and cardiovascular health markers.