Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymorphonuclear leukocytes: dedicated professional phagocytes.

B H Wade, G L Mandell

    The American Journal of Medicine
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Post partum creatine phosphokinase and its muscle-brain isoenzyme elevation and transient Q-wave in a patient with idiopathic hypertrophic subaortic stenosis.

    International journal of obstetric anesthesia·2004
    Same author

    Update in infectious diseases.

    Annals of internal medicine·2001
    Same author

    Effect of epidural analgesia with ambulation on labor duration.

    Anesthesiology·2001
    Same author

    Periosteal entrapment of an epidural catheter in the intrathecal space.

    Anesthesia and analgesia·2001
    Same author

    Uptake, transport, and delivery of antimicrobial agents by human polymorphonuclear neutrophils.

    Antimicrobial agents and chemotherapy·2001
    Same author

    Adequacy of fellowship training: results of a survey of recently graduated fellows.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001

    Polymorphonuclear leukocytes, or PMNs, are key immune cells that engulf and destroy microbes. Understanding PMN function is crucial for diagnosing and treating recurrent infections caused by PMN defects.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Polymorphonuclear leukocytes (PMNs) are essential immune cells, acting as professional phagocytes.
    • These cells originate in bone marrow and circulate to tissues, responding to microbial invasion.
    • Humoral factors and chemotactic substances guide PMNs to infection sites.

    Purpose of the Study:

    • To highlight the critical role of PMNs in host defense against microorganisms.
    • To explain the mechanisms by which PMNs identify, engulf, and kill pathogens.
    • To emphasize the clinical significance of PMN function in recurrent infections.

    Main Methods:

    • Review of established knowledge on PMN development and circulation.
    • Description of chemoattraction, opsonization (antibody and complement), and phagocytosis processes.

    Related Experiment Videos

  • Discussion of microbial killing mechanisms, including oxidative and nonoxidative pathways.

    • Main Results:

    • PMNs are specialized for seeking and destroying invading microorganisms.
    • Antibody and complement enhance PMN phagocytic capabilities.
    • Microbial killing involves both oxidative and nonoxidative intracellular systems.

    Conclusions:

    • Defects in PMN function can lead to severe or recurrent infections.
    • Evaluating PMN function is important in patients with persistent, unusual, or severe infections.
    • Understanding these cellular mechanisms aids in diagnosing and managing infectious diseases.