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Related Experiment Videos

Cortisol in diabetic retinopathy.

R P Bhatia, Adarsh, R H Singh

    Annals of Ophthalmology
    |February 1, 1983
    PubMed
    Summary

    Elevated plasma cortisol levels are linked to diabetic retinopathy development. While both early and advanced stages show higher cortisol, only early stages exhibit increased 17-hydroxycorticosteroids, suggesting cortisol

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    Area of Science:

    • Endocrinology
    • Ophthalmology
    • Metabolic Disorders

    Background:

    • Diabetic retinopathy is a leading cause of vision loss.
    • The role of cortisol in diabetic retinopathy pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate the relationship between plasma cortisol and urinary 17-hydroxycorticosteroids in patients with diabetic retinopathy.

    Main Methods:

    • Evaluated plasma cortisol and urinary 17-hydroxycorticosteroids in 53 patients with early and advanced diabetic retinopathy.
    • Compared levels with 30 control subjects.

    Main Results:

    • Plasma cortisol was significantly elevated in both early and advanced diabetic retinopathy stages.
    • Urinary 17-hydroxycorticosteroids were significantly elevated only in the early stages of diabetic retinopathy.

    Conclusions:

    • Increased plasma cortisol may contribute to the development of diabetic retinopathy.
    • Cortisol metabolism alterations are stage-dependent in diabetic retinopathy.

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