Chronic mucocutaneous candidiasis and keratitis associated with malignant thymoma

Chronic mucocutaneous candidiasis is a rare skin condition that may be associated with immunologic defects, failure of the endocrine system, or a neoplasm, especially thymoma. Ocular findings are rare. Our patients, a middle-aged man, had chronic mucocutaneous candidiasis in conjunction with an aggressive malignant thymoma. He was initially seen with recurrent Candida keratitis and subsequently had Candida esophagitis and a polymicrobial lung abscess. The skin, nail, mucous membrane, and conjunctival involvement responded to oral ketoconazole therapy. This syndrome consists of at least five groups, and various pathogenetic mechanisms and therapeutic agents have been proposed.