Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reduced cortisol latency in depressive illness.

D B Jarrett, P A Coble, D J Kupfer

    Archives of General Psychiatry
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Influence of imipramine on the hypothalamic/pituitary/thyroid axis of the rat.

    Metabolism: clinical and experimental·1998
    Same author

    Inducing lifestyle regularity in recovering bipolar disorder patients: results from the maintenance therapies in bipolar disorder protocol.

    Biological psychiatry·1997
    Same author

    Low rate of membrane lithium transport during treatment correlates with outcome of maintenance pharmacotherapy in bipolar disorder.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·1997
    Same author

    Identifying an abnormal electroencephalographic sleep profile to characterize major depressive disorder.

    Biological psychiatry·1997
    Same author

    Differences over the life span in daily life-style regularity.

    Chronobiology international·1997
    Same author

    Which depressed patients will respond to interpersonal psychotherapy? The role of abnormal EEG sleep profiles.

    The American journal of psychiatry·1997
    Same journal

    Reviewers Who Completed a Review During 2011.

    Archives of general psychiatry·2017
    Same journal

    Conflicts of interest-reply.

    Archives of general psychiatry·2013
    Same journal

    Epidemiologic evidence concerning the bereavement exclusion in major depression-reply.

    Archives of general psychiatry·2013
    Same journal

    This month in archives of general psychiatry.

    Archives of general psychiatry·2013
    Same journal

    About this journal.

    Archives of general psychiatry·2013
    Same journal

    This month in archives of general psychiatry.

    Archives of general psychiatry·2013
    See all related articles

    Depressed patients exhibit altered sleep patterns and cortisol secretion. This study found a disturbed temporal link between sleep onset and cortisol increase in major depressive illness, suggesting a potential biomarker.

    Area of Science:

    • Neuroendocrinology
    • Sleep Medicine
    • Psychiatry

    Background:

    • Depression is frequently associated with disruptions in sleep architecture and cortisol secretion patterns.
    • Understanding the interplay between circadian rhythms, sleep, and the hypothalamic-pituitary-adrenal (HPA) axis is crucial in major depressive illness.

    Purpose of the Study:

    • To investigate sleep-related changes in plasma cortisol concentration in patients with primary major depressive illness.
    • To compare these patterns with those observed in healthy control subjects.
    • To identify potential biological markers for depressive illness.

    Main Methods:

    • Plasma cortisol concentrations were measured in relation to sleep onset in 14 patients with major depressive illness.
    • A control group of 14 age- and sex-matched healthy subjects was included for comparison.

    Related Experiment Videos

  • Analysis focused on the nadir and nocturnal increase in plasma cortisol concentration relative to sleep onset.

    • Main Results:

    • Depressed patients showed a significantly higher nadir of nocturnal plasma cortisol concentration compared to controls.
    • The nocturnal increase in plasma cortisol occurred significantly closer to sleep onset in depressed patients.
    • A disturbed temporal relationship between circadian activity of the HPA axis and sleep onset was observed in depressed individuals.

    Conclusions:

    • The reduced time between sleep onset and the nocturnal cortisol increase in depressed patients suggests a disrupted HPA axis regulation.
    • This finding may represent a subtle but significant biological correlate of major depressive illness.
    • The observed temporal disturbance in cortisol secretion could serve as a potential illness marker for depressed patients.