Profile analysis of volcano field ionization mass spectra of urine from mice with sarcoma I transplanted by...

A group of 20 inbred mice were inoculated intraperitoneally with sarcoma I cells. Urine specimens were collected before and after inoculation from this group as well as from a group of 20 mice for controls. Mass profiles of these groups were obtained by volcano field ion mass spectrometry and compared. Significant differences in average normalized mass peaks between the two groups after inoculations are observed for most of the peaks analysed from mass 84 to 313. There is sufficient diagnostic power in the mass profiles to permit unambiguous separation of the diseased mice from the healthy ones.