Acute hemorrhagic leukoencephalopathy. A clinical, pathological, and radiological correlation

Area of Science:

• Neurology
• Radiology

Background:

• Acute hemorrhagic leukoencephalopathy (AHLE) is a rare and severe neurological disorder.
• Accurate and timely diagnosis is crucial for effective management.

Observation:

• Serial CT scans were performed on two patients diagnosed with AHLE.
• Both patients exhibited significant low-density white matter abnormalities across both cerebral hemispheres.

Findings:

• CT scan findings demonstrated a strong correlation between the observed white matter changes and the clinically affected neurological areas.
• One patient experienced a favorable outcome with complete resolution of CT abnormalities following steroid therapy, suggesting potential therapeutic efficacy.

Implications:

• CT scanning is a valuable tool for diagnosing AHLE, aiding in the identification of characteristic white matter lesions.
• Early diagnosis and prompt initiation of steroid treatment may improve patient prognosis and facilitate radiological recovery in AHLE.