Related Experiment Video
Updated: Mar 4, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
Proper aerosol inhalation technique for delivery of asthma medications
Insights
Many children with asthma struggle with proper inhaler technique, leading to ineffective medication delivery. Educating patients on correct aerosol inhalation is crucial for maximizing the benefits of asthma treatment.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Pharmacology
Background:
- Asthma affects numerous children, requiring consistent medication adherence.
- Metered-dose inhalers (MDIs) are common delivery devices for pediatric asthma patients.
- Proper inhalation technique is essential for effective MDI use.
Purpose of the Study:
- To evaluate the adequacy of aerosol inhalation technique in children with asthma using canister nebulizers.
- To identify common errors in MDI technique among pediatric patients.
- To assess the effectiveness of instruction in correcting MDI technique.
Main Methods:
- Forty-two children (7-15 years) with asthma using canister nebulizers for over 6 months were enrolled.
- A modified nebulizer mouthpiece recorded canister actuation and inhalation.
- Patients' inhalation techniques were assessed, and incorrect techniques were corrected through instruction.
Main Results:
- 18 out of 42 (43%) children demonstrated incorrect aerosol inhalation technique.
- The most frequent error was releasing aerosol without inhaling (11 patients).
- Most children learned the correct technique quickly with instruction and retained it.
Conclusions:
- A significant proportion of children with asthma exhibit suboptimal MDI technique.
- Physician-led education and follow-up are vital for ensuring effective aerosol therapy.
- Improving inhalation technique can enhance medication delivery and asthma management outcomes.
Abstract:
Forty-two (42) children with asthma, 7 to 15 years old, who had been taking aerosol medications from canister nebulizers for longer than 6 months were evaluated for adequacy of aerosol inhalation technique. The mouthpiece of a canister nebulizer was modified so that actuation of the canister and inhalation through the mouthpiece could be recorded. Of 42 patients, 24 had correct inhalation technique (they synchronized the actuation of canister and inhalation); 18 (43%) did not. The most frequent mistake (11 patients) was releasing the aerosol into the mouth without inhaling. Those who inhaled incorrectly were taught the correct technique by repeated instructions and demonstrations; 11 learned it within 5 minutes, but 7 required a longer instruction period. Most had retained the technique when retested later. The physician should teach each patient the correct technique when aerosol therapy is started and should check again on follow-up examinations to assure that the patient obtains maximum benefit from aerosol therapy.
Related Concept Videos
Inhaled Medications
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Additional Routes of Drug Administration
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Antiasthma Drugs: β2-Adrenoceptor Agonists
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...

