Amines induce increased thromboplastin activity in human monocytes

A variety of amines induced a dose-dependent and time-dependent increase in thromboplastin activity of cultured human monocytes. The increase required protein synthesis, and reached a peak after about 18 h. Some inhibitory effects were noted at low concentrations of NH4Cl. It is suggested that the amines act by raising the pH of acidic intracellular compartments.