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Related Experiment Videos

Multiple sclerosis-specific central nervous system antigens (MSG2): a blind study.

S C Rastogi, J Clausen, W W Tourtellotte

    European Neurology
    |January 1, 1983
    PubMed
    Summary
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    A glycoprotein fraction specific for multiple sclerosis (MS) was isolated from central nervous system (CNS) tissue. This marker, MSG2, was found in most MS patients, suggesting a potential viral link.

    Area of Science:

    • Neurology
    • Immunology
    • Virology

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • Previous research identified a glycoprotein fraction (G2) potentially specific to MS.

    Purpose of the Study:

    • To determine if the G2 glycoprotein fraction, specific for MS, could be isolated from cryopreserved autopsy central nervous system (CNS) tissue.
    • To investigate the presence of MS-specific CNS antigens (MSG2) in MS patients compared to other neurological diseases (OND) and controls.

    Main Methods:

    • A blinded study utilized cryopreserved autopsy CNS tissue from MS patients, OND patients, and sudden death controls.
    • Crossed immunoisoelectrophoresis (CIE) was performed to detect the G2 fraction and MSG2.
    • Tandem CIE was used to validate the G2 fraction against a known MSG2 preparation.

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    Main Results:

    • MS-specific CNS antigen (MSG2) was detected in 78% of MS patients' CNS sections.
    • MSG2 was present in all spinal cord sections from MS patients.
    • No MSG2 was found in CNS sections from OND patients or controls.

    Conclusions:

    • The presence of MSG2 in MS CNS tissue supports its specificity for multiple sclerosis.
    • The findings suggest that MSG2 may involve a glycoprotein from a persistent virus, potentially measles or myelin-related.