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Systemic apomorphine reverses intrastriatal dopamine-induced contralateral deviation.

J N Joyce, R E Davis, C Van Hartesveldt

    European Journal of Pharmacology
    |February 18, 1983
    PubMed
    Summary
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    Unilateral dopamine injections into the brain

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Neurochemistry

    Background:

    • Dopamine plays a crucial role in motor control and brain function.
    • The striatum is a key area involved in motor pathways.
    • Apomorphine is a dopamine receptor agonist used to study dopamine system function.

    Purpose of the Study:

    • To investigate the effects of intrastriatal dopamine and apomorphine on postural deviation.
    • To determine if systemically administered apomorphine can modulate dopamine-induced postural changes.
    • To explore the indirect influence of striatal dopamine on extra-striatal dopamine-sensitive sites.

    Main Methods:

    • Unilateral intrastriatal injections of dopamine or apomorphine in animal models.
    • Systemic administration of apomorphine before, during, or after striatal injections.

    Related Experiment Videos

  • Observation and recording of postural deviations as a measure of motor function.

    • Main Results:

    • Intrastriatal dopamine induced contralateral postural deviation.
    • Systemic apomorphine reversed both dopamine- and apomorphine-induced contralateral deviations to ipsilateral deviations.
    • Further intrastriatal dopamine or apomorphine did not alter the contralateral deviation induced by initial dopamine injection.

    Conclusions:

    • Intrastriatal dopamine appears to indirectly influence dopamine-sensitive targets outside the striatum.
    • Systemic apomorphine can counteract the effects of localized striatal dopamine administration.
    • This suggests a complex interplay between striatal and extra-striatal dopamine systems in motor control.