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Activation of fibroblasts induced by mononuclear cells from patients with systemic scleroderma and inactivation by
Dermatologica
|January 1, 1983
Abstract:
Unstimulated mononuclear cell supernatants from patients with systemic scleroderma significantly augmented the DNA and collagen biosynthesis of 3T3 cells compared to normal mononuclear cells. This increase was suppressed by either a particular glycosaminoglycan, which from previous studies, has appeared to act as one of the tissue antigens in sclerotic skin, or concanavalin A stimulation.