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[Therapy of hypertension with timolol, hydrochlorothiazide and amiloride]
Insights
Fixed combination tablets containing timolol, hydrochlorothiazide, and amiloride effectively control blood pressure in hypertensive patients. This combination therapy offers a potent solution for individuals requiring multiple medications for hypertension management.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Hypertension Research
Context:
- Hypertension management often requires combination therapy for optimal blood pressure control.
- Continuous intra-arterial recording provides precise assessment of antihypertensive efficacy.
- Fixed-dose combination tablets offer improved patient compliance and convenience.
Purpose:
- To evaluate the 24-hour effectiveness of a fixed-dose combination tablet (timolol 10 mg, hydrochlorothiazide 25 mg, amiloride 2.5 mg) in ambulant hypertensive patients.
- To assess the impact of this combination therapy on blood pressure responses during isometric and dynamic exercise.
- To determine the advantage of adding a diuretic to a beta-blocker for sustained 24-hour blood pressure control.
Summary:
- Continuous intra-arterial blood pressure monitoring demonstrated a highly significant reduction (p < 0.001) in blood pressure throughout the day with the fixed combination therapy.
- The combination therapy significantly lowered blood pressure responses to both isometric and dynamic exercise.
- Results confirm the potency and utility of this preparation for patients needing multi-drug therapy for hypertension.
Impact:
- The fixed combination tablet is a potent and useful therapeutic option for managing hypertension, particularly in patients requiring multiple agents.
- Combination therapy including a diuretic with a beta-blocker is advantageous for achieving 24-hour blood pressure control.
- This study supports the use of fixed-dose combinations for improving adherence and achieving sustained blood pressure reduction in hypertensive individuals.
Abstract:
The effectiveness of fixed combination tablets of timolol 10 mg. hydrochlorothiazide 25 mg and amiloride 2.5 mg (Moducrin) once daily in the control of blood pressure has been assessed in fully ambulant hypertensives by the technique of continuous intra-arterial recording. Highly significant blood pressure reduction (p less than 0.001) was obtained consistently throughout the whole day, confirming the potency and usefulness of the preparation for those patients who need more than one drug to control their blood pressure. 2. Blood pressure responses to both isometric and dynamic forms of exercise were also significantly lowered by combination therapy. 3. The addition of a diuretic to a beta-adrenoceptor blocker appears to be an advantage if the aim of treatment in hypertension is 24 h blood pressure control.