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Glucose tolerance in patients with cerebrovascular accidents and their blood relatives
Insights
This study investigated hereditary links in abnormal glucose metabolism between stroke patients and their relatives. Results suggest a potential genetic predisposition to glucose intolerance in families affected by cerebrovascular accidents.
Area of Science:
- Endocrinology and Metabolism
- Neurology and Cerebrovascular Disease
Background:
- Abnormal glucose metabolism is a known risk factor for cerebrovascular accidents (stroke).
- The potential hereditary correlation of glucose metabolism abnormalities between stroke patients and their relatives requires further investigation.
Purpose of the Study:
- To examine the hereditary correlation of abnormal glucose metabolism between patients with cerebrovascular accidents and their healthy blood relatives.
- To assess the occurrence of cerebrovascular disease in relation to glucose metabolism.
Main Methods:
- Conducted intravenous glucose tolerance tests (IV-GTT) and prednisolone-primed glucose tolerance tests (PP-GTT) on 83 subjects.
- Subjects included 20 healthy controls, 50 patients with cerebrovascular accidents, and 13 family relatives of the patients.
Main Results:
- Patients with cerebrovascular accidents showed significantly abnormal glucose tolerance (lower k-value in IV-GTT) compared to controls.
- A subset of relatives of stroke patients exhibited abnormal glucose tolerance test results, indicating potential pre-symptomatic diabetes.
- Glucose metabolism abnormalities were observed in patients at varying times post-stroke.
Conclusions:
- The study suggests a possible hereditary component to abnormal glucose metabolism in families with cerebrovascular accidents.
- Findings indicate a need for screening for glucose metabolism disorders in relatives of stroke patients to identify pre-symptomatic diabetes.
Abstract:
The present study was undertaken to examine whether there is any hereditary correlation, with reference to the abnormal glucose metabolism, between patients with cerebrovascular accidents and their healthy blood relatives in respect to the occurrence of cerebrovascular disease. The investigation was carried out by intravenous glucose tolerance test (IV-GTT) and prednisolone-primed glucose tolerance test (PP-GTT) in 83 subjects. Of these, 20 were healthy (control) persons (group A), matched in age and sex with 50 patients with cerebrovascular accidents (group B) and 13 family relatives of group B (group C) showing unequivocal GTT or PP-GTT. In controls, the IV-GTT criterion, i.e. k value, was found generally to be 2.82 +/- 0.43 and in persons less than 50 and over 50 years old, it was found to be related with age, i.e. 3.1 +/- 0.73 and 2.53 +/- 0.43, respectively. The 21 patients of group B with normal GTT response had a k value of 2.53 +/- 1.88 and the 29 patients with abnormal GTT response had a k value of 1.2 +/- 0.33. Among the 21 patients of group B, 11 had normal IV-GTT and their PP-GTT was found to be 125 +/- 12.5 mg%. The other 10 patients with abnormal IV-GTT exhibited a PP-GTT of 173.4 +/- 26.43 mg%. In 14 and 15 patients, the time-lapse difference of 7 and 8-21 days after stroke showed an abnormal GTT response and in 6 and 15 patients it showed a normal response. Among 13 healthy relatives of group B (group C), only 1 subject was found to have abnormal IV-GTT (k value of 1.386) and 2 were found to have abnormal PP-GTT (182.8 and 388.0 mg%), thus indicating pre-symptomatic diabetics.