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Open heart surgery with factor VII deficiency.

C Gagliardi, R D'Avino, P Stassano

The Journal of Cardiovascular Surgery

|March 1, 1983

Summary

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Severe factor VII deficiency was diagnosed in a patient undergoing open heart surgery for atrial myxoma. Successful surgery was performed using factor VII concentrate, preventing bleeding complications.

Area of Science:

Cardiology
Hematology
Surgical Oncology

Background:

Atrial myxoma necessitates surgical intervention, often involving cardiopulmonary bypass.
Coagulation disorders can complicate surgical procedures, increasing risks.
Routine coagulation screening is crucial for identifying underlying hemostatic abnormalities.

Observation:

A patient scheduled for open heart surgery for atrial myxoma presented with unexpectedly low prothrombin activity (22%) on routine preoperative coagulation tests.
Further hematological investigations confirmed a severe deficiency in coagulation factor VII.
The patient's factor VII deficiency was previously undiagnosed.

Findings:

Severe factor VII deficiency was identified as the cause of the abnormal coagulation profile.

Related Experiment Videos

Open heart surgery for atrial myxoma was successfully completed.

Administration of factor VII concentrate effectively managed the bleeding risk during and after surgery.

Implications:

This case highlights the importance of thorough preoperative coagulation assessment, even in the absence of a known bleeding history.
Factor VII concentrate is an effective therapeutic option for managing severe factor VII deficiency during major surgical procedures.
Early diagnosis and management of factor VII deficiency can prevent significant intraoperative and postoperative hemorrhage.