Related Experiment Video

Updated: Aug 9, 2026

Generation of Murine Monoclonal Antibodies by Hybridoma Technology
09:42

Generation of Murine Monoclonal Antibodies by Hybridoma Technology

Published on: January 2, 2017

Monoclonal anti-B produced by the immunization of mice with soluble salivary glycoproteins

E K Barrie, R H Fraser, A C Munro

    Journal of Immunogenetics
    |February 1, 1983
    PubMed

    IgM and IgG mouse monoclonal antibodies with specificity for the blood group B determinant have been produced by immunization of mice with a partially purified salivary glycoprotein. These antibodies have been characterized and one of the IgM antibodies showed potential as a grouping reagent. The ready availability of these salivary blood group substances offers the potential to produce a wide range of related monoclonal antibodies.

    More Related Videos

    Generation of Monoclonal Antibodies Against Natural Products12:15

    Generation of Monoclonal Antibodies Against Natural Products

    Published on: April 6, 2019

    A Method for the Measurement of Salivary Gland Function in Mice07:29

    A Method for the Measurement of Salivary Gland Function in Mice

    Published on: January 25, 2018

    Related Concept Videos

    Hybridoma Technology01:31

    Hybridoma Technology

    Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
    Hybridoma Selection
    Commonly used fusion techniques — electroporation, polyethylene glycol...