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Visual evoked potentials in neurosyphilis.

B Conrad, R Benecke, H Müsers

    Journal of Neurology, Neurosurgery, and Psychiatry
    |January 1, 1983
    PubMed
    Summary
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    Visual evoked potential (VEP) testing revealed abnormalities in 20% of neurosyphilis patients, particularly those with tabes dorsalis. VEP did not outperform other eye exams for diagnosing neurosyphilis.

    Area of Science:

    • Neuro-ophthalmology
    • Infectious Diseases
    • Neurology

    Background:

    • Neurosyphilis is a complex infection affecting the nervous system.
    • Ophthalmological manifestations are common in neurosyphilis.
    • Assessing visual pathway involvement is crucial for diagnosis and management.

    Purpose of the Study:

    • To evaluate the diagnostic utility of pattern reversal visual evoked potential (VEP) in neurosyphilis patients.
    • To determine the prevalence of VEP abnormalities across different neurosyphilis subtypes.
    • To compare VEP sensitivity with other standard ophthalmological tests.

    Main Methods:

    • Pattern reversal visual evoked potential (VEP) was recorded in 79 patients diagnosed with neurosyphilis.
    • VEP latency and amplitude were analyzed.

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  • Results were compared with visual acuity, visual field, pupillary reactions, dark adaptation, and funduscopy findings.

    • Main Results:

    • Abnormal VEP latencies were observed in 16 out of 79 patients (20%).
    • Tabes dorsalis showed the highest rate of abnormal VEPs (50%), followed by general paresis (18%) and meningovascular syphilis (13%).
    • VEP did not demonstrate superior diagnostic accuracy compared to other ophthalmological examinations.

    Conclusions:

    • VEP abnormalities are present in a significant portion of neurosyphilis patients, especially with tabes dorsalis.
    • VEP is not diagnostically superior to conventional ophthalmological tests for neurosyphilis.
    • Further research may explore VEP's role in conjunction with other tests or in specific neurosyphilis stages.