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[Clinical studies on cefadroxil in the field of pediatrics]
Insights
Cefadroxil (CDX) dry syrup demonstrated high clinical efficacy (98.4%) in treating mild pediatric bacterial infections. Bacteriological eradication rates were also high (93.3%) with minimal adverse reactions observed.
Area of Science:
- Pharmacology
- Pediatric Infectious Diseases
- Antimicrobial Therapy
Context:
- Cefadroxil (CDX) is a newly developed dry syrup formulation.
- Pediatric patients with various mild bacterial infections were studied.
- Treatment duration averaged 8 days with varying daily dosages and administration frequencies.
Purpose:
- To evaluate the clinical and bacteriological efficacy of cefadroxil dry syrup in children.
- To assess adverse reactions associated with cefadroxil dry syrup administration.
- To compare clinical outcomes based on different daily dosages and administration frequencies.
Summary:
- Cefadroxil dry syrup achieved an overall clinical efficacy of 98.4% across 64 pediatric cases, including tonsillitis, scarlet fever, and urinary tract infections.
- Bacteriological eradication was successful in 93.3% of evaluable cases.
- Higher daily doses (31-40 mg/kg) showed a greater excellent response rate compared to lower doses (≤30 mg/kg) in tonsillitis cases.
- While no significant difference was noted between 3 or 4 times daily administration, pharmacokinetic considerations suggest the latter may be preferable.
- Adverse reactions were minimal, with transient eosinophilia and minor elevations in liver enzymes and BUN observed in a small percentage of patients.
Impact:
- Cefadroxil dry syrup is confirmed as a useful therapeutic option for mild pediatric bacterial infections.
- The study provides evidence supporting optimal dosing and administration strategies for cefadroxil in pediatric populations.
- Findings contribute to the understanding of cefadroxil's safety and effectiveness profile in children.
Abstract:
The newly developed cefadroxil (CDX) dry syrup in a mean daily dose of 32.9 mg/kg t.i.d. or q.i.d. was administered to children for a period of 8 days on the average; viz. a total of 64 cases consisting of 39 cases of tonsillitis, 2 of tonsillitis complicated with otitis media, 1 of bronchitis, 1 of pneumonia, 14 of scarlet fever, and 7 of urinary tract infections; and its clinical and bacteriological effects, and adverse reactions were examined, leading to the following results. 1. The clinical effects were "good" or "excellent" in any of 39 cases of tonsillitis, 2 of tonsillitis complicated with otitis media, 1 of pneumonia, 14 of scarlet fever, and 7 of urinary tract infections, and "fair" only in a case of bronchitis, showing the high efficacy of 98.4%. 2. The clinical effects by daily dose were compared only in the great cases of tonsillitis between the 2 daily dose groups of 30 mg/kg or below and 31 to 40 mg/kg, and both groups showed "good" or "excellent" results, but the latter group revealed that the excellent rate was greater by 20.8% than that of the former group. 3. The frequency of daily administration was 3 times or 4 times and the cases of 4 times administration were few in any disease. In comparison of clinical effects between the 3 times group and the 4 times group in the whole cases, no significant difference was observed between both groups but it is desirable to make the 4 times administration in view of the pharmacokinetics. 4. The bacteriological effects could be judged in 15 cases, namely bacteria were eradicated in 14 cases and unchanged in 1 case, showing a good result of the eradication rate as 93.3%. 5. No adverse reaction was observed and the laboratory test values showed eosinophilia in 7 cases (15.9%) and abnormal elevations of GPT in 1 case (4.5%), of GOT and GPT in 2 case (9.1%), of LDH in 1 case (4.8%) and of BUN in 1 case (4.8%), but 4 of the 7 cases with eosinophilia seemed attributable to underlying diseases or objective diseases. From the above it can be said that this preparation is a useful drug in mild bacterial diseases.