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Related Experiment Videos

Apolipoprotein E and cholesterol metabolism.

R W Mahley

    Klinische Wochenschrift
    |March 1, 1983
    PubMed
    Summary

    Apolipoprotein E (apo-E) mediates lipoprotein receptor interactions. Studies reveal lysine, arginine residues, and specific apo-E regions are crucial for this binding process, highlighting genetic heterogeneity impacts.

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    Apolipoprotein E: far more than a lipid transport protein.

    Annual review of genomics and human genetics·2001

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Genetics

    Background:

    • Apolipoprotein E (apo-E) plays a key role in lipoprotein metabolism.
    • Understanding apo-E's function is vital for lipoprotein receptor interactions.

    Purpose of the Study:

    • To investigate the role of specific amino acid residues in apo-E function.
    • To explore the structure-function relationships of apo-E isoforms.

    Main Methods:

    • Selective chemical modification of lipoprotein amino acid residues.
    • Structure-function studies using mutant forms of apo-E.

    Main Results:

    • Lysine and arginine residues are important for lipoprotein-receptor interactions mediated by apo-E.
    • Genetic heterogeneity of apo-E isoforms influences binding.
    • A specific region of apo-E is critical for the binding process.

    Conclusions:

    • Specific amino acid residues and regions of apo-E are essential for its function in lipoprotein binding.
    • Apo-E isoforms exhibit genetic heterogeneity that impacts receptor interactions.

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