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Ventilatory transients during exercise: peripheral or central control?

R Favier, D Desplanches, J Frutoso

    Pflugers Archiv : European Journal of Physiology
    |March 1, 1983
    PubMed
    Summary
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    The fast component of exercise ventilation is primarily controlled by mechanoreceptors, not venous return changes or beta-blockers. Central depressants, however, do alter this breathing pattern.

    Area of Science:

    • Exercise Physiology
    • Respiratory Control

    Background:

    • The rapid ventilatory response during exercise transitions is crucial for matching gas exchange to metabolic demand.
    • Understanding the control mechanisms of this rapid phase is essential for comprehending exercise limitations and respiratory regulation.

    Purpose of the Study:

    • To investigate if changes in venous return (exercise intensity, beta-blockade) affect the fast ventilatory component during exercise transitions.
    • To determine if central ventilatory depressants alter the fast ventilatory component during exercise.

    Main Methods:

    • Awake dogs were trained to run on a treadmill to study ventilatory responses.
    • Experiments involved varying exercise workloads and administering beta-adrenergic blocking agents and central depressants.

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    Main Results:

    • Ventilation changes at exercise onset showed no correlation with exercise intensity.
    • Ventilatory decline post-exercise correlated with work performed; neither was affected by beta-blockade.
    • Central depressants significantly altered the breathing pattern of the fast ventilatory component.

    Conclusions:

    • The fast ventilatory component during exercise transitions is reflexly controlled by mechanoreceptors.
    • Cerebral control is superimposed on this reflex mechanism to regulate tidal volume and breathing rate.