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Related Experiment Videos

Lipoprotein profile--its value in prediction.

A Keys

    Preventive Medicine
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    High levels of high-density lipoprotein (HDL) cholesterol may not protect against coronary heart disease mortality. This 25-year study found no significant link, suggesting a potential trade-off with cancer mortality.

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    Area of Science:

    • Cardiovascular Health
    • Lipid Metabolism
    • Epidemiology

    Background:

    • The prevailing belief is that high-density lipoprotein (HDL) cholesterol protects against coronary heart disease (CHD).
    • Previous studies often focused on disease incidence rather than long-term mortality and used short follow-up periods.
    • Some reports suggest an inverse relationship between HDL and mortality, but with questionable data and short follow-up.

    Purpose of the Study:

    • To investigate the long-term relationship between plasma high-density lipoprotein (HDL) cholesterol concentration and all-cause and coronary heart disease (CHD) mortality.
    • To re-examine the protective role of HDL cholesterol in light of mortality data over an extended follow-up period.

    Main Methods:

    • A 25-year follow-up study of Minnesota business and professional men aged 50-60 at entry.

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  • Annual examinations and mortality data collection through 1978, including 135 deaths (55 from CHD).
  • Statistical analysis of plasma HDL cholesterol concentration in relation to mortality outcomes.

    • Main Results:

    • No significant association was found between plasma HDL cholesterol concentration and total or coronary heart disease mortality.
    • The data suggest a potential direct relationship between HDL cholesterol levels and mortality from neoplastic diseases (cancer).
    • A possible trade-off between coronary heart disease mortality and cancer mortality concerning HDL cholesterol levels was observed.

    Conclusions:

    • The popular notion that higher HDL cholesterol levels are always beneficial for preventing coronary heart disease needs reevaluation.
    • Long-term mortality data do not support a protective effect of HDL cholesterol against CHD mortality.
    • Further research is warranted to explore the complex relationship between HDL cholesterol, cancer risk, and overall mortality.