Spontaneous changes in risk factors and prediction of coronary heart disease

European cohorts of the Seven Countries Study have been analyzed in order to examine relationships between the observed incidence of coronary heart disease (CHD) in the second 5-year period of the follow-up and the major risk factors and their spontaneous changes in the first 5 years. The analysis, using the Multiple Logistic Function (MLF) model, shows that changes of systolic blood pressure and smoking habits were significant factors associated with CHD incidence, whereas changes of cholesterol and body mass index were not.