Elevated creatine phosphokinase levels associated with influenza A/Texas/1/77 infection

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Updated: Aug 9, 2026

High-throughput Detection Method for Influenza Virus
10:05

High-throughput Detection Method for Influenza Virus

Published on: February 4, 2012

H A Kessler, G M Trenholme, N J Vogelzang

    Scandinavian Journal of Infectious Diseases
    |January 1, 1983
    PubMed

    Insights

    Elevated creatine phosphokinase (CPK) levels were common in hospitalized influenza A patients. This may indicate skeletal muscle involvement by the influenza virus, leading to increased costs and complications.

    Area of Science:

    • Virology
    • Clinical Medicine
    • Pathology

    Background:

    • Influenza A virus infections can lead to various clinical manifestations.
    • The potential for skeletal muscle involvement in influenza requires further investigation.

    Purpose of the Study:

    • To investigate the prevalence and implications of elevated creatine phosphokinase (CPK) levels in hospitalized patients with influenza A infection.

    Main Methods:

    • Retrospective analysis of 24 hospitalized patients with confirmed influenza A.
    • Measurement of creatine phosphokinase (CPK) levels.
    • Review of clinical data, including hospital costs and complications.
    • Analysis of muscle biopsies from two patients.

    Main Results:

    • 14 out of 24 patients exhibited elevated CPK levels not explained by other causes.
    • Muscle biopsies revealed focal necrosis and myopathic changes in two patients.
    • Influenza A/Texas/1/77 was isolated from one biopsy specimen.
    • Patients with elevated CPK levels experienced higher daily hospital costs and more complications.

    Conclusions:

    • Elevated CPK levels are a relatively common finding in hospitalized influenza A patients.
    • Influenza virus may directly affect skeletal muscle, causing myopathy.
    • Elevated CPK levels in influenza patients are associated with increased healthcare utilization and adverse outcomes.

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