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Malathion percutaneous absorption after repeated administration to man.
Toxicology and Applied Pharmacology
|March 30, 1983
Summary
Single-dose malathion absorption studies accurately predict chronic exposure risks. This research found no significant difference in percutaneous absorption between single and repeated malathion applications in humans.
Area of Science:
- Toxicology
- Dermatology
- Environmental Health
Background:
- Pesticide risk assessment often relies on acute, single-dose exposure data.
- Chronic daily exposure is a more relevant scenario for pesticides like malathion, especially during public health applications.
Purpose of the Study:
- To determine the percutaneous absorption of chronically applied malathion in humans.
- To compare chronic malathion absorption to single-dose absorption rates.
Main Methods:
- Human male volunteers received initial topical [14C]malathion application.
- Repeated non-radioactive malathion applications were administered to the same site.
- Absorption was assessed by comparing radioactivity from single and repeated applications.
Main Results:
- Percutaneous absorption from the first [14C]malathion application was 4.48 +/- 1.3%.
- Absorption from the second application was 3.53 +/- 1.0%, which was not significantly different (p > 0.05).
Conclusions:
- Single-dose percutaneous absorption data for malathion are relevant for predicting toxic potential during longer-term exposures.
- Findings suggest current risk assessment models for malathion may be adequate for chronic exposure scenarios.