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Intradermal BCG vaccination complications--analysis of 51 cases

G R de Souza, C C Sant'Anna, J R Lapa e Silva

    Tubercle
    |March 1, 1983
    PubMed

    Insights

    Local complications from intradermal BCG vaccination, including abscesses and enlarged lymph nodes, occurred in 51 children. Treatment with isoniazid or surgical drainage yielded favorable outcomes in all cases.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Vaccinology

    Background:

    • Bacille Calmette-Guérin (BCG) vaccination is a crucial tool for preventing tuberculosis.
    • Intradermal BCG administration can lead to localized adverse events.
    • Understanding the spectrum and management of these complications is important for public health.

    Purpose of the Study:

    • To report the incidence and characteristics of local complications following intradermal BCG vaccination.
    • To describe the clinical presentation and treatment outcomes of these complications in children.

    Main Methods:

    • Retrospective review of 51 cases of local BCG vaccination complications.
    • Data collected from children aged 0-16 years in Niteroi between 1974 and 1979.
    • Analysis of lesion types, treatment modalities, and patient outcomes.

    Main Results:

    • 51 local complications were identified in 117,533 vaccinated children.
    • Common complications included abscesses, lymph node enlargement, and chronic ulceration.
    • All patients treated with isoniazid or surgical drainage showed favorable results.

    Conclusions:

    • Local complications from intradermal BCG vaccination are infrequent but can manifest as various skin and lymph node issues.
    • Isoniazid is an effective treatment for most BCG-associated local complications.
    • Prompt diagnosis and appropriate management ensure favorable outcomes.

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