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Related Experiment Videos

Digoxin kinetics in the elderly.

J Reid, R D Kennedy, F I Caird

    Age and Ageing
    |February 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    This study on elderly patients found that digoxin toxicity is linked to reduced kidney function and longer drug elimination times. Systemic toxicity cases showed the highest digoxin body content.

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    Area of Science:

    • Pharmacokinetics
    • Geriatric Medicine
    • Toxicology

    Background:

    • Digoxin is a common medication for heart conditions in the elderly.
    • Understanding digoxin elimination is crucial for safe dosing, especially in older adults.
    • Digoxin toxicity can present with varying clinical signs and symptoms.

    Purpose of the Study:

    • To investigate the elimination phase kinetics of digoxin in elderly inpatients.
    • To compare renal function, digoxin half-life, volume of distribution, and body content between toxic and non-toxic patients.
    • To explore the impact of conditions like thyrotoxicosis on digoxin pharmacokinetics.

    Main Methods:

    • Studied 24 elderly inpatients (mean age 79 years).
    • Grouped patients based on observed digoxin effects (toxicity vs. non-toxicity).

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  • Assessed renal function (creatinine clearance), digoxin elimination half-life, apparent volume of distribution, and estimated body content.

    • Main Results:

    • Toxic patients generally had lower creatinine clearance and longer digoxin half-lives than non-toxic patients.
    • The apparent volume of digoxin distribution averaged 6.1 L/kg, excluding two hyperthyroid patients.
    • The highest digoxin body content was observed in patients with systemic toxicity.
    • Thyrotoxicosis was associated with an increased apparent volume of digoxin distribution in the elderly.

    Conclusions:

    • Digoxin toxicity in the elderly is associated with impaired renal function and prolonged elimination.
    • Systemic toxicity correlates with the highest digoxin body burden.
    • Thyrotoxicosis significantly alters digoxin distribution in elderly patients, necessitating careful dosage adjustments.