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Related Experiment Videos

Serum enzyme changes during marathon training.

F S Apple, M K McGue

    American Journal of Clinical Pathology
    |June 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Intense marathon training can alter blood enzyme levels in runners, potentially mimicking organ damage. Creatine kinase (CK) and lactate dehydrogenase (LD) changes may lead to misdiagnosis of heart or liver conditions.

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    Area of Science:

    • Sports Medicine
    • Clinical Biochemistry
    • Exercise Physiology

    Background:

    • Long-distance running, particularly marathon training, places significant physiological stress on the body.
    • Elevated blood enzyme levels are common indicators of organ damage, including cardiac and hepatic conditions.
    • Understanding exercise-induced enzymatic changes is crucial for accurate medical diagnosis in athletes.

    Purpose of the Study:

    • To investigate changes in blood enzyme activities in marathon runners during intense training.
    • To determine if these enzymatic alterations could be misinterpreted as organ-specific damage.
    • To assess the diagnostic implications of cardiac and hepatic enzyme elevations in healthy athletes.

    Main Methods:

    • Monitoring of blood enzyme activities over a six-week training period in two male marathon runners.

    Related Experiment Videos

  • Specific measurement of creatine kinase (CK) and lactate dehydrogenase (LD) isoenzymes.
  • Analysis of alanine transaminase (ALT) as a marker for hepatic enzyme activity.

    • Main Results:

    • Significant alterations observed in CK and LD isoenzymes in both runners.
    • Runner B showed a reversed LD1/LD2 isoenzyme ratio concurrent with sustained MB CK elevation.
    • Runner A experienced transient elevation of the hepatic enzyme ALT.
    • These findings indicate potential for misdiagnosis of myocardial infarction and liver disease.

    Conclusions:

    • Elevated cardiac isoenzymes (MB CK, LD1) and hepatic enzyme ALT during marathon training can mimic organ damage.
    • Athletes undergoing intense training may present with enzyme profiles suggestive of myocardial infarction or liver disease.
    • Careful interpretation of enzyme levels in the context of athletic training is essential to avoid inappropriate clinical diagnoses.