Related Experiment Video
Updated: Oct 9, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
'Recurrent' erythroblastopenia of childhood. An IgM-mediated RBC aplasia
Abstract:
An anemia of childhood with reticulocytopenia and marrow RBC aplasia was found to be due to immune-mediated erythropoietic suppression. In vitro assays of marrow and peripheral blood erythroid progenitors indicated normal cell numbers that markedly declined when autologous serum or IgM was added to the cultures, but remained unchanged with autologous IgG or with autologous serum depleted of IgM. In contrast to "transient" erythroblastopenia of childhood, this anemia was recurrent, lasted longer, and seemed to be prednisone responsive.
More Related Videos
11:59Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
08:44Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Related Concept Videos
Erythropoiesis
Rh Blood Group
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Cytomegalovirus Disease