Normal range of plasma fibrinogen.

Area of Science:

• Biochemistry
• Clinical Chemistry
• Hematology

Background:

• Fibrinogen is a key protein in blood coagulation.
• Establishing accurate normal ranges for plasma proteins is crucial for clinical diagnostics.
• Previous studies have not fully characterized the distribution of fibrinogen concentration.

Purpose of the Study:

• To determine the normal range of fibrinogen concentration using an automated method.
• To investigate the distribution pattern of plasma fibrinogen.
• To assess the influence of age and sex on fibrinogen levels.

Main Methods:

• Utilized an automated thrombin time procedure for fibrinogen measurement.
• Analyzed the distribution of measured fibrinogen concentrations.
• Stratified results based on patient age and sex.

Main Results:

• The distribution of fibrinogen concentration was found to be non-Gaussian.
• Significant age- and sex-dependent variations in fibrinogen levels were observed.
• The 95% confidence interval for normal fibrinogen concentration was established as 145-348 mg/dl.

Conclusions:

• The normal range for fibrinogen concentration is best represented by a non-Gaussian distribution.
• Age and sex are important factors influencing normal fibrinogen levels.
• The established 145-348 mg/dl range provides a more accurate reference for clinical interpretation.