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Related Experiment Videos

Hyperlactacidemia associated with acute ritodrine infusion.

S R Richards, F E Chang, L E Stempel

    American Journal of Obstetrics and Gynecology
    |May 1, 1983
    PubMed
    Summary

    Beta-mimetic tocolytics, like ritodrine, can cause dangerous lactic acidosis. This study found ritodrine significantly increased lactate levels in patients, highlighting risks of tocolytic therapy.

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    Area of Science:

    • Obstetrics and Gynecology
    • Pharmacology
    • Clinical Biochemistry

    Background:

    • Beta-mimetic tocolytics are used to prevent premature labor.
    • Previous reports suggest potential metabolic derangements, including lactic acidosis, with beta-mimetic tocolytics, especially when combined with steroids.

    Purpose of the Study:

    • To prospectively investigate and clarify the occurrence of hyperlactacidemia (elevated blood lactate) in patients receiving different tocolytic agents.
    • To assess the impact of concomitant steroid administration on lactate levels during tocolysis.

    Main Methods:

    • A prospective study involving twenty patients in premature labor.
    • Patients received either ritodrine alone, ritodrine plus hydrocortisone, hydrocortisone alone, or magnesium sulfate alone.
    • Blood lactate levels were measured and compared to baseline.

    Main Results:

    • Intravenous infusion of ritodrine for 6 hours led to a significant increase in blood lactate levels (from 1.0 +/- 0.1 mmol/L to 3.5 +/- 0.3 mmol/L).
    • No significant changes in lactate levels were observed in groups receiving ritodrine plus hydrocortisone, hydrocortisone alone, or magnesium sulfate alone.

    Conclusions:

    • Ritodrine monotherapy is associated with a marked increase in blood lactate levels, suggesting a risk of hyperlactacidemia.
    • The findings underscore the importance of monitoring metabolic alterations, particularly lactate levels, in patients undergoing beta-mimetic tocolysis.

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