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[Current histopathological findings in Ménière's disease]
Abstract:
Controversy exists as to the presence of ruptures of the membranous labyrinth in patients with Meniere's disease, some authors considering the lesions reported to be artefacts only. Confirmation of the existence of healed labyrinthine tears was obtained in all cases of clinically and histopathologically confirmed Menière's disease studied by means of a protocol involving strict criteria. Lesions were observed mainly in Reissner's membrane and demonstrated three particular aspects. It is suggested that the images described by Out-Pouch in the posterior labyrinth are also the result of healed ruptures.
Insights
This study confirms healed ruptures in the membranous labyrinth of Meniere's disease patients, primarily affecting Reissner's membrane. These findings challenge the notion that reported lesions are merely artefacts.
Area of Science:
- Otolaryngology
- Neuroscience
- Pathology
Context:
- Meniere's disease is a disorder of the inner ear.
- The presence of ruptures in the membranous labyrinth in Meniere's disease is debated.
- Some researchers believe reported lesions are artefacts.
Purpose:
- To confirm the existence of healed labyrinthine tears in Meniere's disease.
- To investigate the characteristics and location of these lesions.
Summary:
- Healed labyrinthine tears were confirmed in all studied cases of Meniere's disease using strict criteria.
- Lesions were predominantly observed in Reissner's membrane.
- Three distinct aspects of these lesions were identified.
- It is hypothesized that Out-Pouch images in the posterior labyrinth are also healed ruptures.
Impact:
- Provides histopathological evidence supporting the existence of labyrinthine tears in Meniere's disease.
- Contributes to a better understanding of the pathophysiology of Meniere's disease.
- May influence diagnostic criteria and treatment strategies for Meniere's disease.