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Related Experiment Videos

Postictal elevation of serum creatine kinase level.

A L Chesson, E J Kasarskis, V W Small

    Archives of Neurology
    |May 1, 1983
    PubMed
    Summary

    Serum creatine kinase (CK) levels significantly increase after seizures, especially tonic-clonic or focal motor types. Muscle activity intensity and alcohol abuse correlate with higher postictal CK elevations.

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    Area of Science:

    • Neurology
    • Biochemistry

    Background:

    • Seizures can cause physiological changes.
    • Creatine kinase (CK) is an enzyme released from damaged muscle.

    Purpose of the Study:

    • To investigate postictal serum creatine kinase (CK) levels.
    • To correlate CK elevation with seizure characteristics and patient factors.

    Main Methods:

    • Prospective study of patients following seizures.
    • Serial serum CK level measurements over six days.
    • CK isoenzyme analysis.

    Main Results:

    • All patients showed elevated serum CK levels post-seizure.
    • CK elevations were linked to skeletal muscle.
    • Profound CK increases correlated with seizure intensity and alcohol abuse.

    Conclusions:

    • Significant postictal serum CK elevation is common after seizures.
    • Elevated CK levels originate from skeletal muscle.
    • Seizure intensity and alcohol use impact postictal CK levels.

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