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Baclofen. Its effect on seizure frequency.

C F Terrence, G H Fromm, M S Roussan

    Archives of Neurology
    |January 1, 1983
    PubMed
    Summary
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    Baclofen, a medication, did not worsen seizures in epilepsy patients. In controlled epilepsy cases, baclofen showed no adverse effects on seizure frequency.

    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Baclofen's epileptogenic potential in humans contrasts with its demonstrated anticonvulsant effects in animal models.
    • The clinical impact of baclofen on patients with epilepsy remains incompletely understood.

    Purpose of the Study:

    • To investigate the effect of baclofen on seizure frequency in patients with a history of epilepsy.
    • To determine if baclofen has a deleterious effect on seizure control in epileptic individuals.

    Main Methods:

    • A cohort of 12 patients with epilepsy received baclofen at conventional dosages.
    • Patients were stratified based on seizure control (controlled vs. uncontrolled epilepsy).
    • Seizure frequency was monitored during baclofen therapy.

    Main Results:

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    • In six patients with seizure-controlled epilepsy, no seizures occurred during baclofen treatment.
    • In six patients with uncontrolled epilepsy, two experienced an increase in seizure frequency.
    • One patient with uncontrolled epilepsy showed a significant reduction in monthly seizures.

    Conclusions:

    • Baclofen does not appear to exacerbate seizure activity in patients with epilepsy.
    • The drug may not have a detrimental effect on seizure control, even in challenging cases.
    • Further research could explore baclofen's specific role in epilepsy management.