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Related Experiment Videos

Urine and plasma propranolol.

F Andreasen, P Jakobsen, H J Kornerup

    Clinical Pharmacology and Therapeutics
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    This study found that propranolol plasma concentrations in hypertensive patients can be estimated using urinary excretion and orosomucoid levels. These methods offer a way to calculate average free and total propranolol levels for therapeutic monitoring.

    Area of Science:

    • Pharmacokinetics
    • Clinical Pharmacology

    Background:

    • Long-term propranolol therapy is common for hypertension.
    • Accurate monitoring of propranolol plasma concentrations is crucial for effective treatment.
    • Existing methods for determining propranolol levels can be complex.

    Purpose of the Study:

    • To establish reliable methods for calculating average free and total propranolol plasma concentrations in hypertensive patients.
    • To explore the relationship between urinary excretion, orosomucoid levels, and propranolol plasma concentrations.
    • To validate these calculation methods against direct plasma measurements.

    Main Methods:

    • Studied eight hypertensive patients on long-term propranolol therapy during a 24-hour inpatient stay.
    • Measured total and free plasma propranolol concentrations and urinary excretion of unchanged drug.

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  • Developed equations to calculate average free propranolol from urinary excretion and average total propranolol from free propranolol and orosomucoid levels.

    • Main Results:

    • A significant relationship was found between calculated and directly measured average free propranolol plasma concentrations (r = 0.98).
    • A significant correlation was observed between calculated and directly measured average total propranolol plasma levels (r = 0.91).
    • Orosomucoid concentration correlated positively with the reciprocal of the free propranolol fraction in plasma.

    Conclusions:

    • Urinary excretion and orosomucoid concentration can be used to estimate average 24-hour free and total propranolol plasma concentrations.
    • The proposed calculation methods are reliable within the studied concentration ranges (y free < 30 ng/ml, y total < 400 ng/ml).
    • These findings suggest a practical approach for therapeutic drug monitoring of propranolol in hypertensive patients.