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Immunoreactive relaxin-like substance in human split ejaculates.

S De Cooman, P Gilliaux, K Thomas

    Fertility and Sterility
    |January 1, 1983
    PubMed
    Summary
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    Relaxin concentrations in seminal plasma are higher in the first ejaculate fraction. This suggests an extragonadic source, likely the prostate, especially in cases of congenital agenesis of the vasa deferentia and seminal vesicles.

    Area of Science:

    • Reproductive Endocrinology
    • Urology
    • Andrology

    Background:

    • Relaxin is a hormone with known reproductive roles.
    • Its presence and source in human seminal plasma require further investigation.

    Purpose of the Study:

    • To investigate the concentration and potential source of immunoreactive relaxin-like substance in human seminal plasma.
    • To compare relaxin levels in normozoospermic individuals, split ejaculates, and patients with azoospermia.

    Main Methods:

    • Quantification of immunoreactive relaxin-like substance in seminal plasma.
    • Analysis of whole seminal plasma, split ejaculates, and seminal plasma from patients with excretory azoospermia.

    Main Results:

    • Relaxin concentration was significantly higher in the first fraction of split ejaculates (P < 0.001).

    Related Experiment Videos

  • In azoospermia post-vasectomy or epididymal obstruction, relaxin levels were similar to normozoospermic individuals.
  • Elevated relaxin concentrations were observed in congenital agenesis of vasa deferentia and seminal vesicles.
  • Conclusions:

    • Human seminal plasma relaxin appears to originate from an extragonadic source.
    • The prostate is a probable localization for this extragonadic relaxin source.
    • Relaxin levels may provide insights into male reproductive tract pathologies.