[Mitochondria as possible "targets" in neuroallergy]

During experimental allergic encephalomyelitic (EAE) in dogs, it was established with electron microscope that mitochondria of neurons and glia of the central nervous system (CNS) were most sensitive organelles to the development of neuroallergy. Swelling of mitochondria, disruption of their membranes, desorganization of mitochondrian cristae were observed in the incubation period; these alterations were seen increasing by the moment of clinical manifestation of EAE. Immunization of guinea pigs by mitochondrial fractions of dog's brain cortex with Freund's adjuvant resulted in the manifestation of clinical and morphological signs of EAE in the CNS in addition to a significant destruction of mitochondria. The idea of the initial alteration of different membranous structures of the CNS during demyelinating processes in brain is put forward.