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Amiodarone-induced polymorphous ventricular tachycardia.

S Sclarovsky, R F Lewin, O Kracoff

    American Heart Journal
    |January 1, 1983
    PubMed
    Summary
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    Amiodarone can cause a dangerous heart rhythm called polymorphous ventricular tachycardia (torsade de pointes), leading to fainting. Standard treatments were effective but required prolonged therapy due to amiodarone

    Area of Science:

    • Cardiology
    • Pharmacology
    • Electrophysiology

    Background:

    • Amiodarone is an antiarrhythmic drug.
    • Polymorphous ventricular tachycardia (torsade de pointes) is a potentially fatal arrhythmia.
    • Prolonged QT interval is a risk factor for torsade de pointes.

    Observation:

    • Five cases of amiodarone-induced polymorphous ventricular tachycardia (torsade de pointes) are presented.
    • All patients experienced recurrent syncope or dizziness.
    • Prolonged QT interval was observed in all patients.

    Findings:

    • Hypokalemia was present in two cases but did not resolve the arrhythmia upon correction.
    • Standard treatments including isoproterenol and ventricular pacing were successful.
    • Treatment duration was extended (5-10 days) likely due to amiodarone's long elimination half-life.

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    Implications:

    • Amiodarone requires careful monitoring for potential cardiac side effects.
    • Extended treatment duration may be necessary for amiodarone-induced torsade de pointes.
    • Understanding amiodarone's pharmacokinetics is crucial for managing associated arrhythmias.