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Leishmaniasis affecting the eyelids.

F C Chu, M M Rodrigues, D G Cogan

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |January 1, 1983
    PubMed
    Summary
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    Leishman-Donovan bodies in an eyelid ulcer were identified as Leishmania braziliensis panamensis. Treatment with pentavalent antimony was effective, and ultrastructural analysis revealed key organism features.

    Area of Science:

    • Parasitology
    • Tropical Medicine
    • Dermatology

    Background:

    • Leishmaniasis is a neglected tropical disease caused by Leishmania parasites.
    • Ocular leishmaniasis presents a diagnostic and therapeutic challenge.
    • Early identification of Leishmania species is crucial for effective treatment.

    Observation:

    • Leishman-Donovan bodies were observed in an eyelid ulcer biopsy smear.
    • The causative agent was serologically identified as Leishmania braziliensis panamensis.
    • The patient's eyelid ulcer responded successfully to pentavalent antimony therapy.

    Findings:

    • Ultrastructural examination revealed double-unit membranes surrounding the Leishmania parasites.
    • A palisade of microtubules was noted beneath the organism's membrane.

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  • A rudimentary flagellum and nucleus were identified, separated by a kinetoplast basal complex.

    • Implications:

    • This case highlights the successful treatment of ocular leishmaniasis caused by Leishmania braziliensis panamensis.
    • Understanding the ultrastructure of Leishmania parasites aids in diagnostics and drug development.
    • Early diagnosis and appropriate treatment are vital for managing cutaneous and ocular leishmaniasis.