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Local and systemic effects of pindolol eye drops
British Journal of Clinical Pharmacology
|January 1, 1983
Summary
Pindolol eye drops effectively lower intraocular pressure at both 1% and 0.25% concentrations. However, the lower concentration showed less effect in inhibiting exercise-induced tachycardia, indicating a dose-dependent systemic effect.
Area of Science:
- Ophthalmology
- Pharmacology
- Cardiovascular Physiology
Background:
- Pindolol is a non-selective beta-adrenergic receptor antagonist.
- Ophthalmic beta-blockers are used to reduce intraocular pressure.
- Systemic absorption of topical eye drops can cause cardiovascular effects.
Purpose of the Study:
- To evaluate the local and systemic effects of two different concentrations of pindolol eye drops.
- To compare the efficacy of 1% and 0.25% pindolol in reducing intraocular pressure.
- To assess the impact of these concentrations on exercise-induced heart rate.
Main Methods:
- A balanced cross-over, double-blind study design.
- Involvement of 12 healthy volunteers.
- Administration of 1% and 0.25% pindolol eye drops.
- Measurement of intraocular pressure and heart rate response to exercise.
Main Results:
- Both 1% and 0.25% pindolol eye drops significantly reduced intraocular pressure.
- The reduction in intraocular pressure was comparable between the two concentrations.
- Inhibition of exercise-induced tachycardia was significantly less pronounced with the 0.25% concentration compared to the 1% concentration.
Conclusions:
- Pindolol eye drops demonstrate efficacy in lowering intraocular pressure at both tested concentrations.
- The systemic effect on heart rate during exercise is concentration-dependent, with lower concentrations having a reduced impact.
- These findings suggest a potential for tailored dosing of pindolol eye drops to balance local efficacy and minimize systemic side effects.