Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paracetamol absorption from Paramax, Panadol and Solpadeine.

J R Dougall, B Cunningham, W S Nimmo

    British Journal of Clinical Pharmacology
    |April 1, 1983
    PubMed
    Summary

    Solpadeine, containing paracetamol with codeine and caffeine, showed significantly higher paracetamol concentrations compared to Panadol (paracetamol alone) at 15 minutes. Paramax (paracetamol with metoclopramide) absorption was comparable to both formulations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Many-body theory calculations of positronic-bonded molecular dianions.

    The Journal of chemical physics·2024
    Same author

    Many-Body Theory Calculations of Positron Scattering and Annihilation in H_{2}, N_{2}, and CH_{4}.

    Physical review letters·2023
    Same author

    Use of a door handle disinfection system to reduce the risks associated with microbial loads on fomites in a healthcare setting.

    The Journal of hospital infection·2022
    Same author

    What are the risk factors for complications after combined injury of the pelvic ring and acetabulum?

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2022
    Same author

    Performance monitoring of mycobacterium tuberculosis dried culture spots for use with the GeneXpert system within a national program in South Africa.

    Journal of clinical microbiology·2013
    Same author

    Histological Changes in the Rat Testis Following Heat Treatment.

    The Yale journal of biology and medicine·2011

    Area of Science:

    • Pharmacokinetics and Drug Absorption
    • Pharmaceutical Formulation Analysis
    • Clinical Pharmacology

    Background:

    • Paracetamol is a widely used analgesic and antipyretic.
    • Various pharmaceutical preparations combine paracetamol with other active ingredients to potentially enhance efficacy or absorption.
    • Understanding the comparative absorption profiles of different paracetamol formulations is crucial for optimizing pain management.

    Purpose of the Study:

    • To compare the plasma paracetamol concentrations after oral administration of three different pharmaceutical preparations.
    • To evaluate the absorption rate of paracetamol from formulations containing additional active ingredients.

    Main Methods:

    • Four healthy volunteers received oral doses of three paracetamol formulations: Paramax (paracetamol/metoclopramide), Solpadeia (paracetamol/codeine/caffeine), and Panadol (paracetamol alone).

    Related Experiment Videos

  • Plasma paracetamol concentrations were measured at specific time points post-administration.
  • Statistical analysis was performed to compare concentration differences between formulations.

    • Main Results:

    • Significantly higher plasma paracetamol concentrations were observed at 15 minutes after administration of Solpadeia compared to Panadol.
    • The absorption of paracetamol from Paramax did not show significant differences when compared to Solpadeia or Panadol.
    • These findings suggest a faster absorption rate for paracetamol in the Solpadeia formulation.

    Conclusions:

    • The combination of paracetamol with codeine and caffeine in Solpadeia leads to a more rapid absorption of paracetamol compared to paracetamol alone (Panadol).
    • Paramax formulation demonstrates comparable paracetamol absorption kinetics to both Solpadeia and Panadol.
    • Formulation composition significantly influences the absorption rate of paracetamol.