Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective stabilization of muscle innervation during development: a mathematical model.

J L Gouzé, J M Lasry, J P Changeux

    Biological Cybernetics
    |January 1, 1983
    PubMed
    Summary

    This study models how skeletal muscle innervation stabilizes, with active nerve terminals competing for a retrograde factor (mu). This competition ensures only one nerve ending per muscle fiber stabilizes, matching experimental data.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Towards a cognitive neuroscience of self-awareness.

    Neuroscience and biobehavioral reviews·2016
    Same author

    Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata.

    Molecular pharmacology·2015
    Same author

    Comparison of embryonic and adult torpedo acetylcholine receptor by sedimentation characteristics and antigenicity.

    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2014
    Same author

    Errata.

    The Journal of membrane biology·2013
    Same author

    Changes in extrinsic fluorescence intensity of the electroplax membrane during electrical excitation.

    The Journal of membrane biology·2013
    Same author

    In Vitro excitation of purified membrane fragments by cholinergic agonists : I. Pharmalogical properties of the excitable membrane fragments.

    The Journal of membrane biology·2013

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Developmental Biology

    Background:

    • Skeletal muscle innervation involves initial over-innervation by motor axons.
    • This redundant innervation is later refined to a single nerve terminal per muscle fiber.

    Purpose of the Study:

    • To present a biochemical model for the selective stabilization of skeletal muscle innervation.
    • To explain the mechanism behind the elimination of supernumerary nerve terminals.

    Main Methods:

    • Developed a biochemical model based on competition for a postsynaptic retrograde factor (mu).
    • Utilized mathematical analysis and computer simulations to validate the model.
    • Assumed constant numbers of motoneurons and muscle fibers during innervation development.

    Related Experiment Videos

    Main Results:

    • The model predicts a unique, physically acceptable solution where only one nerve terminal stabilizes per muscle fiber.
    • The model explains observed variations in motor unit size and innervation patterns.
    • It accounts for activity-dependent modulation of innervation regression.

    Conclusions:

    • The competition for the retrograde factor mu drives the selective stabilization of nerve endings.
    • The model successfully replicates key experimental observations in skeletal muscle innervation.
    • It provides a biochemical basis for understanding the refinement of neuromuscular junctions.