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Synaptic development and microtubule organization.

L E Westrum, E G Gray, R D Burgoyne

    Cell and Tissue Research
    |January 1, 1983
    PubMed
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    Microtubules (mts) play a crucial role in forming and maintaining presynaptic dense projections (pre-dps) in developing rat brain cortices. These structures may guide synaptic vesicles to their release sites.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Developmental Biology

    Background:

    • The precise mechanisms governing the formation of synaptic structures, particularly presynaptic dense projections (pre-dps), remain incompletely understood.
    • Microtubules (mts) are fundamental components of neuronal architecture, but their specific role in synaptogenesis is an area of ongoing investigation.

    Purpose of the Study:

    • To investigate the structural relationship between microtubules and the developing presynaptic apparatus in rat brain cortices.
    • To elucidate the potential role of microtubules in the initial formation and maintenance of presynaptic dense projections.

    Main Methods:

    • Utilized enhanced microtubular preservation techniques, including albumin pretreatment.
    • Examined occipital and pyriform cortices of developing rats via electron microscopy at various developmental stages.

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    Main Results:

    • Observed a close structural association between microtubules, focal membrane densities, synaptic vesicles, and presynaptic dense projections during neuronal maturation.
    • In neonates, microtubules were seen to focus on immature axonic profiles, with focal densities appearing at these attachment sites.
    • Synaptic vesicles were subsequently observed to associate with microtubules and abut these developing presynaptic structures.

    Conclusions:

    • Microtubules may be integral to the initial formation of presynaptic dense projections.
    • Microtubules might also contribute to the maintenance of presynaptic dense projections in adult neurons.
    • Microtubules could function to direct initial synaptic vesicle trafficking to sites of synaptic contact and neurotransmitter release.