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Related Experiment Videos

Submitral atheromatous lesions in monkey and man.

S Feinstein, R Pick, I D'Cruz

    Clinical Cardiology
    |March 1, 1983
    PubMed
    Summary

    Posterior submitral recess (PSMR) calcification, often found in elderly individuals, appears to be linked to atherosclerosis and hypertension. Studies show PSMR changes resemble atheroma and can be replicated in monkeys with high-fat diets and hypertension.

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    Area of Science:

    • Cardiovascular Pathology
    • Atherosclerosis Research
    • Geriatric Medicine

    Background:

    • Posterior submitral recess (PSMR) calcification is a frequent autopsy finding in the elderly.
    • The exact cause of PSMR calcification remains unclear.
    • Preliminary observations suggest PSMR changes may be atheroma-like.

    Purpose of the Study:

    • To investigate the pathogenesis of posterior submitral recess (PSMR) calcification.
    • To determine the relationship between PSMR changes, atherosclerosis, and hypertension.
    • To establish an animal model for studying PSMR pathology.

    Main Methods:

    • Autopsy analysis of PSMR findings in human subjects.
    • Statistical correlation of PSMR changes with clinical data (hypertension) and autopsy findings (coronary atherosclerosis).

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  • Experimental induction of PSMR changes in macaque monkeys fed high-fat, high-cholesterol diets, with and without induced hypertension.

    • Main Results:

    • PSMR changes at autopsy exhibit atheroma-like characteristics, including lipid deposits around sclerosis and calcification.
    • A significant correlation was found between PSMR changes and the presence of hypertension.
    • PSMR changes also correlated significantly with severe coronary atherosclerosis.
    • Similar fibrosis and lipid deposition in the PSMR were successfully replicated in macaque monkeys under specific dietary and hypertensive conditions.

    Conclusions:

    • The pathogenesis of posterior submitral recess (PSMR) calcification is strongly associated with atherosclerosis.
    • Hypertension is a significant contributing factor to PSMR changes.
    • Experimental models in non-human primates demonstrate that atherosclerosis and hypertension can induce PSMR pathology, mirroring findings in humans.