Effect of norethisterone on seizures associated with menstruation

The effect of high and low doses of norethisterone on seizure frequency was studied in nine epileptic patients, aged 20-30 years. All patients satisfied the defined criteria of having catamenial exacerbation. The study was double blind, placebo controlled, and randomised. Each patient was followed through four menstrual cycles with each drug dose and also with placebo. The results of this study suggest that norethisterone is not effective in the control of seizures associated with the menstrual period.